|
KMID : 1161420100130020352
|
|
Journal of Medicinal Food
2010 Volume.13 No. 2 p.352 ~ p.356
|
|
|
Assessment of Anti-Inflammatory and Antinociceptive Activities of Olea europaea L.
|
|
Suntar Ipek Pesin
Akkol Esra Kupeli
Baykal Turhan
|
|
|
Abstract
|
|
|
|
Leaves and fruits of Olea europaea L. (Family Oleaceae) are used for the treatment of various kinds of diseases, i.e., rheumatism and hemorrhoids, and as a vasodilator in vascular disorders for ages in folk medicine. In order to evaluate this information, anti-inflammatory and antinociceptive activities of the ethanolic and n-hexane extracts prepared from the fruits of O. europaea were investigated. For the anti-inflammatory activity, the carrageenan-induced hind paw edema and acetic acid-induced increased capillary permeability models were used, whereas for the antinociceptive activity, the p-benzoquinone-induced writhing and hot plate tests in mice were used. The results revealed that the ethanolic extract did not show a significant anti-inflammatory or analgesic activity, whereas the n-hexane extract displayed 12.7?27.8% inhibition on the carrageenan-induced hind paw edema model at the 400?mg/kg dose, without inducing any apparent acute toxicity as well as gastric damage. Further studies are warranted to define and isolate the active anti-inflammatory and antinociceptive components from this plant, which may yield safe and effective agents to be used in the treatment of inflammatory disorders.
|
|
|
KEYWORD
|
|
|
acetic acid-induced increased capillary permeability, p-benzoquinone-induced abdominal constriction, carrageenan-induced hind paw edema, hot plate, Oleaceae
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|
|